Cristoforo Comi, MD, PhD

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CURRENT POSITION Assistant Professor of Neurology Department of Clinical and Experimental Medicine University of Eastern Piedmont “Amedeo Avogadro” Maggiore Hospital, Novara, Italy Tel. number: Office: +39-0321-3733965 Lab: +39-0321-660658 Fax number: +39-0321-3733298 E-mail: comi@med.unipmn.it

EDUCATION

2002-2006. PhD in Molecular Medicine, University of Eastern Piedmont “Amedeo Avogadro”.

2001-2002. Fellowship in Neurology, Mount Sinai School of Medicine, New York, USA.

1997-2002. Residency, Department of Neurology, University of Eastern Piedmont “Amedeo Avogadro”. Graduated cum laude.

1994-1996. Internship, Department of Neurology, L. Sacco Hospital, University of Milan. 1990-1996. School of Medicine, University of Milan. Graduated cum laude.

PROFESSIONAL MEMBERSHIPS

Member of the Italian Society of Neurology

Member of the Italian Association of Neuroimmunology

EXPERIENCE

Clinical experience

2006-present. Attending physician at the In-Patient Clinic, Department of Neurology, University of Eastern Piedmont “Amedeo Avogadro”, Novara Italy.

2006-present. Attending physician at the Neuroimmunology Clinic, University of Eastern Piedmont “Amedeo Avogadro”, Novara Italy.

1997-present. Attending physician at the Multiple Sclerosis Center, University of Eastern Piedmont “Amedeo Avogadro”, Novara Italy.

1997-present. Attending physician at the Movement Disorders Center, University of Eastern Piedmont “Amedeo Avogadro”, Novara Italy.

1997-2002. Neurology Resident at the in-patient Clinic, Department of Neurology, University of Eastern Piedmont “Amedeo Avogadro”, Novara Italy.

Research experience

2006-present. Collaboration with the Neurorehabilitation Center M.L. Novarese, Moncrivello (Vc).

1998-present. Collaboration with the Interdisciplinary Research Center on Autoimmune Diseases, University of Eastern Piedmont “Amedeo Avogadro”, Novara Italy. Worked in laboratory of Prof U. Dianzani, studying - (a) genes involved in the immune system in relation to multiple sclerosis, inflammatory neuropathies, neurodegenerative diseases. (b) the role of Fas system in the pathogenesis of multiple sclerosis and inflammatory neuropathies.

1994-1996. Graduate Student, Laboratory of Neurochemistry, L. Sacco Hospital, University of Milan. Worked in laboratory of Dr. P. Bertora, studying the role of neurotransmitters in HIV encephalopathy.

Teaching Experience

2007-present. Faculty Member of the PhD Program in Molecular Medicine. University of Eastern Piedmont “Amedeo Avogadro”.

2007-present. Course of Neurophysiology. School of Occupational therapy. Cattolica University, Rome.

2006-present. Course of Neurological Semeiology. Residency in Neurology, University of Eastern Piedmont “Amedeo Avogadro”.

2006-present. Course of Clinical Neurology School of Radiologic & X-ray Technician. University of Eastern Piedmont “Amedeo Avogadro”.

2004-present. Course of Neurological Semeiology. Course of Clinical Neurology. School of Medicine, University of Eastern Piedmont “Amedeo Avogadro”.

1997-present. Course of Neurophysiology. Course of Neurological Semeiology. Course of Clinical Neurology. School of Phisical Therapy and Rehabilitation, University of Eastern Piedmont “Amedeo Avogadro”.

Editorial Experience

Associate Editor of Journal of Alzheimer’s Disease

Member of the Editorial Board of International Journal of Clinical and Experimental Medicine

Ad hoc reviewer of the following journals/scientific societies:

Expert Review of Clinical Immunology (2010)

Neurolgical Sciences (2009)

Journal of Alzheimer’s Disease (2008)

Archives of Neurology (2007)

European Journal of Neurology (2007)

Current Aging Science (2007)

The Parkinson's Disease Society of the United Kingdom (2007)

Journal of Neuroimmunology (2006)

Annals of Neurology (2001, 2004, 2005)

Neurology (2001)

AWARDS

● Annual Congress of the Italian Society of Neurology. Best Poster Presentation, 2006.

● Servizi Interbancari-Cartasi. Best Graduate Student Award, 1996

PUBLICATIONS:

Original Articles:

1: Benedetti L, Briani C, Fazio R, Prolasso I, Comi C, Luigetti M, Sabatelli M, Giannini F, Schenone A, Nobile-Orazio E, Cocito D. Rituximab in patients with CIDP: A report of 13 cases and review of the literature. J Neurol Neurosurg Psychiatry 2010 in press.

2: Comi C, Carecchio M, Chiocchetti A, Nicola S, Galimberti D, Fenoglio C, Cappellano G, Monaco F, Scarpini E, Dianzani U. Osteopontin is increased in the cerebrospinal fluid of patients with Alzheimer’s disease and its levels correlate with cognitive decline. J Alzheimers Dis. 2009 in press

3: Cocito D, Prolasso I, Antonimi G, Benedetti L, Briani C, Comi C, Fazio R, Jann S, Matà S, Mazzeo A, Sabatelli M, Nobile-Orazio E .A nationwide retrospective analysis on the effect of immune therapies in patients with Chronic Inflammatory Demyelinating Polyradiculoneuropathy. Eur J Neurol. 2009 in press

4: Comi C, Osio M, Ferretti M, Mesturini R, Cappellano G, Chiocchetti A,

Carecchio M, Nascimbene C, Varrasi C, Cantello R, Mariani C, Monaco F, Dianzani

U. Defective Fas-mediated T-cell apoptosis predicts acute onset CIDP. J Peripher

Nerv Syst. 2009;14:101-6.

5: Carecchio M, Fenoglio C, De Riz M, Guidi I, Comi C, Cortini F, Venturelli E, Restelli I, Cantoni C, Bresolin N, Monaco F, Scarpini E, Galimberti D. Progranulin plasma levels as potential biomarker for the identification of GRN deletion carriers. A case with atypical onset as clinical amnestic Mild Cognitive Impairment converted to Alzheimer's disease. J Neurol Sci. 2009. [Epub ahead of print]

6: Carecchio M, Comi C, Varrasi C, Stecco A, Sainaghi PP, Bhatia K, Carriero A, Cantello R, Monaco F. Complex movement disorders in primary antiphospholipid syndrome: a case report. J Neurol Sci. 2009;281:101-3.

7: Fedi M, Cantello R, Shuey NH, Mitchell LA, Comi C, Monaco F, Versino M. Spontaneous intracranial hypotension presenting as a reversible dorsal midbrain syndrome. J Neuroophthalmol. 2008;28:289-92.

8: Cappellano G, Orilieri E, Comi C, Chiocchetti A, Bocca S, Boggio E, Bernardone IS, Cometa A, Clementi R, Barizzone N, D'Alfonso S, Corrado L, Galimberti D, Scarpini E, Guerini FR, Caputo D, Paolicelli D, Trojano M, Figà-Talamanca L, Salvetti M, Perla F, Leone M, Monaco F, Dianzani U. Variations of the perforin gene in patients with multiple sclerosis. Genes Immun. 2008;9:438-44.

9: Galimberti D, Fenoglio C, Comi C, Scalabrini D, De Riz M, Leone M, Venturelli E, Cortini F, Piola M, Monaco F, Bresolin N, Scarpini E. MDC/CCL22 intrathecal levels in patients with multiple sclerosis. Mult Scler. 2008;14:547-9.

10: Galimberti D, Scalabrini D, Fenoglio C, De Riz M, Comi C, Venturelli E, Cortini F, Piola M, Leone M, Dianzani U, D'Alfonso S, Monaco F, Bresolin N, Scarpini E. Gender-specific influence of the chromosome 16 chemokine gene cluster on the susceptibility to Multiple Sclerosis. J Neurol Sci. 2008;267:86-90.

11: Scalabrini D, Fenoglio C, Scarpini E, De Riz M, Comi C, Venturelli E, Cortini F, Piola M, Villa C, Naldi P, Monaco F, Bresolin N, Galimberti D. Candidate gene analysis of SPARCL1 gene in patients with multiple sclerosis. Neurosci Lett. 2007;425:173-6.

12: Castelli L, Comi C, Chiocchetti A, Nicola S, Mesturini R, Giordano M, D'Alfonso S, Cerutti E, Galimberti D, Fenoglio C, Tesser F, Yagi J, Rojo JM, Perla F, Leone M, Scarpini E, Monaco F, Dianzani U. ICOS gene haplotypes correlate with IL10 secretion and multiple sclerosis evolution. J Neuroimmunol. 2007;186:193-8.

13: Galimberti D, Scalabrini D, Fenoglio C, Comi C, De Riz M, Venturelli E, Lovati C, Mariani C, Monaco F, Bresolin N, Scarpini E. CXCL10 haplotypes and multiple sclerosis: association and correlation with clinical course. Eur J Neurol. 2007;14:162-7.

14: Mesturini R, Nicola S, Chiocchetti A, Bernardone IS, Castelli L, Bensi T, Ferretti M, Comi C, Dong C, Rojo JM, Yagi J, Dianzani U. ICOS cooperates with CD28, IL-2, and IFN-gamma and modulates activation of human naïve CD4+ T cells. Eur J Immunol. 2006;36:2601-12.

15: Comi C, Gaviani P, Leone M, Ferretti M, Castelli L, Mesturini R, Ubezio G, Chiocchetti A, Osio M, Muscia F, Bogliun G, Corso G, Gavazzi A, Mariani C, Cantello R, Monaco F, Dianzani U. Fas-mediated T-cell apoptosis is impaired in patients with chronic inflammatory demyelinating polyneuropathy. J Peripher Nerv Syst. 2006;11:53-60.

16: Scalabrini D, Galimberti D, Fenoglio C, Comi C, De Riz M, Venturelli E, Castelli L, Piccio L, Ronzoni M, Lovati C, Mariani C, Monaco F, Bresolin N, Scarpini E. P-selectin glycoprotein ligand-1 variable number of tandem repeats (VNTR) polymorphism in patients with multiple sclerosis. Neurosci Lett. 2005;388:149-52.

17: Galimberti D, Fenoglio C, Clerici R, Comi C, De Riz M, Rottoli M, Piccio L, Ronzoni M, Venturelli E, Monaco F, Poloni M, Bresolin N, Scarpini E. E-selectin A561C and G98T polymorphisms influence susceptibility and course of multiple sclerosis. J Neuroimmunol. 2005;165:201-5.

18: Chiocchetti A, Comi C, Indelicato M, Castelli L, Mesturini R, Bensi T, Mazzarino MC, Giordano M, D'Alfonso S, Momigliano-Richiardi P, Liguori M, Zorzon M, Amoroso A, Trojano M, Monaco F, Leone M, Magnani C, Dianzani U. Osteopontin gene haplotypes correlate with multiple sclerosis development and progression. J Neuroimmunol. 2005;163:172-8.

19: Osio M, Zampini L, Muscia F, Valsecchi L, Comi C, Cargnel A, Mariani C. Cutaneous silent period in human immunodeficiency virus-related peripheral neuropathy. J Peripher Nerv Syst. 2004;9:224-31.

20: Lombardi G, Miglio G, Canonico PL, Naldi P, Comi C, Monaco F. Abnormal response to glutamate of T lymphocytes from multiple sclerosis patients. Neurosci Lett. 2003;340:5-8.

21: Cantello R, Boccagni C, Comi C, Civardi C, Monaco F. Diagnosis of psychogenic

paralysis: the role of motor evoked potentials. J Neurol. 2001;248:889-97.

22: Comi C, Leone M, Bonissoni S, DeFranco S, Bottarel F, Mezzatesta C, Chiocchetti A, Perla F, Monaco F, Dianzani U. Defective T cell fas function in patients with multiple sclerosis. Neurology. 2000;55:921-7.

Invited Book Chapters:

1. Monaco F, Comi C. Anticonvulsant Drugs and Cognitive Functions in Elderly Patients with Epilepsy, in Behavioral Neurology in the Elderly, Leon-Carrion J, Giannini MJ; CRC Press, New York, 2000: 403-408.